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432 High p53 activity reduces the transcription of SLC7A11 and the antioxidant potential of frataxin-deficient cells, therefore, inhibiting P53 activity to improve system Xc and GSH content may be a potential therapeutic strategy to combat oxidative stress and possible ferroptosis in Friedreichs Ataxia

Inflammation serves to facilitate the delivery of immune cells, chemical messengers, and antibodies to a site of injury or infection

Intragastric and oral administration give detectable plasma levels for several hours in rodent studies, supported by the proline-rich sequence resisting cleavage by gastric proteases

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